Article
Correlations of Calf Muscle Macrophage Content With Muscle Properties and Walking Performance in Peripheral Artery Disease.
Journal of the American Heart Association - 18 May 2020
Kosmac Kate, Gonzalez-Freire Marta, McDermott Mary M, White Sarah H, Walton R Grace, Sufit Robert L, Tian Lu, Li Lingyu, Kibbe Melina R, Criqui Michael H, Guralnik Jack M, S Polonsky Tamar, Leeuwenburgh Christiaan, Ferrucci Luigi, Peterson Charlotte A
Abstract excerpt
Background Peripheral artery disease (PAD) is a manifestation of atherosclerosis characterized by reduced blood flow to the lower extremities and mobility loss. Preliminary evidence suggests PAD damages skeletal muscle, resulting in muscle impairments that contribute to functional decline. We sought to determine whether PAD is associated with an altered macrophage profile in gastrocnemius muscles and whether...
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