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Article

The forkhead transcription factor, FOXP3: a critical role in male fertility in mice.

Biology of reproduction - 1 Jan 2014

Jasurda Jake S, Jung Deborah O, Froeter Erin D, Schwartz David B, Hopkins Torin D, Farris Corrie L, McGee Stacey, Narayan Prema, Ellsworth Buffy S

Abstract excerpt

Fertility is dependent on the hypothalamic-pituitary-gonadal axis. Each component of this axis is essential for normal reproductive function. Mice with a mutation in the forkhead transcription factor gene, Foxp3, exhibit autoimmunity and infertility. We have previously shown that Foxp3 mutant mice have significantly reduced expression of pituitary gonadotropins. To address the role of Foxp3 in gonadal function,...

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Source

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Identifiers

PMID: 24258212
DOI: 10.1095/biolreprod.113.112375
PMCID: PMC4076402

Genes

FOXP3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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