Article
Scurfy, the Foxp3 locus, and the molecular basis of peripheral tolerance.
Current topics in microbiology and immunology - 1 Jan 2008
Appleby M W, Ramsdell F
Abstract excerpt
The ability to rapidly and efficiently recognize and eliminate pathogens while sparing normal self tissue is a hallmark of the mammalian immune system. When it fails, however, autoimmune disease results. The genetic and environmental factors that control the process of making such distinctions, not to mention the specific targeted tissues, are extraordinarily complex in the human population; only now are we...
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