Genetic Variants at the NAT2 and HLA-DOA are Associated With Anti-Tuberculosis Drug-Induced Liver Injury Susceptibility and Clinical Manifestations in Western Chinese Populations.

doi:10.1002/iid3.70517

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Genetic Variants at the NAT2 and HLA-DOA are Associated With Anti-Tuberculosis Drug-Induced Liver Injury Susceptibility and Clinical Manifestations in Western Chinese Populations.

Immunity, inflammation and disease - 1 Sept 2026

Zhao Zhenzhen, Wang Dongmei, Si Yanjun, Zhou Yanhong, Ruan Hongxia, Ying Binwu, Chen Hao

Abstract excerpt

BACKGROUND: Anti-tuberculosis drug-induced liver injury (ATDILI) is one of the most prevalent and serious adverse reactions during anti-tuberculosis treatment and can potentially lead to liver failure or mortality. This study aims to investigate whether genetic variants in the N-acetyltransferase 2 gene (NAT2) and the HLA-DOA gene (HLA-DOA) are associated with ATDILI susceptibility and clinical manifestations in...

Read the complete abstract on PubMed

Topics

Adult
Female
Humans
Male
Middle Aged
Antitubercular Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Arylamine N-Acetyltransferase

Chemical and Drug Induced Liver Injury

China

Genetic Predisposition to Disease

Genotype

Polymorphism, Single Nucleotide

Tuberculosis

East Asian People

Source

Open in PubMed Open full text

Identifiers

PMID: 42742466
DOI: 10.1002/iid3.70517
PMCID: PMC13576906

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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