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Article

Aberrant PI3Kδ splice isoform as a potential biomarker and novel therapeutic target for endocrine cancers

21 Aug 2023

Abstract excerpt

Introduction PI3K/AKT signaling pathway is upregulated in a broad spectrum of cancers. Among the class I PI3Ks (PI3Kδ/β/δ isoforms), PI3Kδ has been implicated in hematologic cancers and solid tumors. Alternative splicing is a post-transcriptional process for acquiring proteomic diversity in eukaryotic cells. Emerging evidence has highlighted the involvement of aberrant mRNA splicing in cancer...

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PMID: 37670888
DOI: 10.3389/fendo.2023.1190479

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