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Article

The ASXL1-G643W variant accelerates the development of CEBPA mutant acute myeloid leukemia.

Haematologica - 1 Apr 2021

D'Altri Teresa, Wilhelmson Anna S, Schuster Mikkel B, Wenzel Anne, Kalvisa Adrija, Pundhir Sachin, Meldgaard Hansen Anne, Porse Bo T

Abstract excerpt

ASXL1 is one of the most commonly mutated genes in myeloid malignancies, including Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML). In order to further our understanding of the role of ASXL1 lesions in malignant hematopoiesis, we generated a novel knock-in mouse model carrying the most frequent ASXL1 mutation identified in MDS patients, p.G643WfsX12. Mutant mice did not display any major...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32381577
DOI: 10.3324/haematol.2019.235150
PMCID: PMC8017816

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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