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Article

Dose-response relationships of propranolol in Chinese subjects with different CYP2D6 genotypes.

Journal of the Chinese Medical Association : JCMA - 1 Jan 2003

Huang Chin-Wei, Lai Ming-Liang, Lin Min-Shung, Lee Hwei-Ling, Huang Jin-Ding

Abstract excerpt

BACKGROUND: For clinical treatment, a smaller dosage of propranolol is often used among Chinese people. Propranolol is metabolized by polymorphic CYP2D6. We postulate that the lower propranolol dosage in Chinese is due to a slower CYP2D6 metabolism. A majority of the Chinese population has the nucleotide T188 in the CYP2D6 gene (CYP2D6*10) instead of C188 (CYP2D6*1), which most white subjects have. Chinese...

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PMID: 12728976

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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