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Article

LKB1 coordinates neurite remodeling to drive synapse layer emergence in the outer retina.

eLife - 7 May 2020

Burger Courtney A, Alevy Jonathan, Casasent Anna K, Jiang Danye, Albrecht Nicholas E, Liang Justine H, Hirano Arlene A, Brecha Nicholas C, Samuel Melanie A

Abstract excerpt

Structural changes in pre and postsynaptic neurons that accompany synapse formation often temporally and spatially overlap. Thus, it has been difficult to resolve which processes drive patterned connectivity. To overcome this, we use the laminated outer murine retina. We identify the serine/threonine kinase LKB1 as a key driver of synapse layer emergence. The absence of LKB1 in the retina caused a marked...

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Identifiers

PMID: 32378514
DOI: 10.7554/eLife.56931
PMCID: PMC7237215

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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