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The absence of BBSome function decreases synaptogenesis and causes ectopic synapse formation in the retina

20 May 2020

Abstract excerpt

Abstract Photoreceptors possess ribbon synapses distinct from the conventional synapses in the brain. Little is known about the function of the BBSome, a complex integral in ciliary and intracellular trafficking, in ribbon synaptic formation. We performed immunohistochemistry using retinas from Bardet-Biedl Syndrome (BBS) mouse models and found that BBS mutant animals have significantly fewer ribbon synapses in...

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PMID: 32433491
DOI: 10.1038/s41598-020-65233-4

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