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Article

The cytoplasmic tail of rhodopsin triggers rapid rod degeneration in kinesin-2 mutants.

The Journal of biological chemistry - 20 Oct 2017

Feng Dong, Chen Zhe, Yang Kuang, Miao Shanshan, Xu Bolin, Kang Yunsi, Xie Haibo, Zhao Chengtian

Abstract excerpt

Photoreceptor degeneration can lead to blindness and represents the most common form of neural degenerative disease worldwide. Although many genes involved in photoreceptor degeneration have been identified, the underlying mechanisms remain to be elucidated. Here we examined photoreceptor development in zebrafish kif3a and kif3b mutants, which affect two subunits of the kinesin-2 complex. In both mutants, rods...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 28855254
DOI: 10.1074/jbc.M117.784017
PMCID: PMC5655514

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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