Article
MERTK-Dependent Ensheathment of Photoreceptor Outer Segments by Human Pluripotent Stem Cell-Derived Retinal Pigment Epithelium.
Stem cell reports - 10 Mar 2020
Almedawar Seba, Vafia Katerina, Schreiter Sven, Neumann Katrin, Khattak Shahryar, Kurth Thomas, Ader Marius, Karl Mike O, Tsang Stephen H, Tanaka Elly M
Abstract excerpt
Maintenance of a healthy photoreceptor-retinal pigment epithelium (RPE) interface is essential for vision. At the center of this interface, apical membrane protrusions stemming from the RPE ensheath photoreceptor outer segments (POS), and are possibly involved in the recycling of POS through phagocytosis. The molecules that regulate POS ensheathment and its relationship to phagocytosis remain to be deciphered. By...
Topics
- Cell Line
- Human Embryonic Stem Cells
- Humans
- Ligands
- Mutation
- Phagocytosis
- Pluripotent Stem Cells
- Receptors, Vitronectin
- Retinal Photoreceptor Cell Outer Segment
- Retinal Pigment Epithelium