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Segregation of mtDNA mutations protects mitochondria across kingdoms, with impacts from longevity to agriculture and evolvability.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences - 2 Apr 2026

Johnston Iain G

Abstract excerpt

Mitochondrial DNA (mtDNA) encodes essential bioenergetic and metabolic machinery across eukaryotes, but it is susceptible to mutational damage. The high copy number, physical location and inheritance patterns of mtDNA mean that specialist approaches to mitigate such damage are needed. A common theme across many species is segregation or 'sorting out' of different mtDNA types-generating variance in mutant...

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Identifiers

PMID: 41923598
DOI: 10.1098/rstb.2025.0075

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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