A randomized, double-blind, placebo-controlled trial of testosterone for treatment of postmenopausal women with aromatase inhibitor-induced arthralgias: Alliance study A221102.

doi:10.1007/s00520-020-05473-2

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A randomized, double-blind, placebo-controlled trial of testosterone for treatment of postmenopausal women with aromatase inhibitor-induced arthralgias: Alliance study A221102.

Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer - 1 Jan 2021

Cathcart-Rake Elizabeth, Novotny Paul, Leon-Ferre Roberto, Le-Rademacher Jennifer, Storrick Elizabeth M, Adjei Araba A, Terstriep Shelby, Glaser Rebecca, Giuliano Armando, Mitchell William R, Page Seth, Austin Colleen, Deming Richard L, Ferreira Margaret A, Lafky Jacqueline M, Birrell Stephen N, Loprinzi Charles L

Abstract excerpt

PURPOSE: To evaluate the efficacy of testosterone supplementation for improving aromatase inhibitor musculoskeletal symptoms (AIMSS). METHODS: Postmenopausal women experiencing moderate-to-severe arthralgias while taking adjuvant aromatase inhibitors for breast cancer were enrolled in this trial. Initially, patients were randomly allocated to receive either a subcutaneous testosterone pellet versus a placebo...

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PMID: 32372176
DOI: 10.1007/s00520-020-05473-2
PMCID: PMC7644633

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TNFSF11

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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