Article

Methotrexate for the treatment of osteoarthritis: a systematic review and meta-analysis of randomized controlled trials

2025-11-04

Abstract excerpt

<title>Abstract</title> <p>Methotrexate (MTX) has been proposed to treat osteoarthritis (OA) because of its anti-inflammatory effects, but randomized trial results are inconsistent. We performed a systematic review and meta-analysis of randomized trials to clarify MTX’s efficacy and safety in adults with knee or hand OA. We searched MEDLINE, Embase, CENTRAL, and ClinicalTrials.gov from inception through July 2025...

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Literature Corpus work: 61f9d73c-1284-52bc-bdc0-2453b2735a68
DOI: 10.21203/rs.3.rs-8012800/v1

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