A Cohort Study to Evaluate Genetic Predictors of Aromatase Inhibitor Musculoskeletal Symptoms: Results from ECOG-ACRIN E1Z11.

doi:10.1158/1078-0432.CCR-23-2137

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Article

A Cohort Study to Evaluate Genetic Predictors of Aromatase Inhibitor Musculoskeletal Symptoms: Results from ECOG-ACRIN E1Z11.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jul 2024

Stearns Vered, Jegede Opeyemi A, Chang Victor T-S, Skaar Todd C, Berenberg Jeffrey L, Nand Ranveer, Shafqat Atif, Jacobs Nisha L, Luginbuhl William, Gilman Paul, Benson Al B, Goodman Judie R, Buchschacher Gary L, Henry N Lynn, Loprinzi Charles L, Flynn Patrick J, Mitchell Edith P, Fisch Michael J, Sparano Joseph A, Wagner Lynne I

Abstract excerpt

PURPOSE: Aromatase inhibitor (AI)-associated musculoskeletal symptoms (AIMSS) are common and frequently lead to AI discontinuation. SNPs in candidate genes have been associated with AIMSS and AI discontinuation. E1Z11 is a prospective cohort study designed to validate the association between 10 SNPs and AI discontinuation due to AIMSS. PATIENTS AND METHODS: Postmenopausal women with stage I to III hormone...

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Identifiers

PMID: 38640040
DOI: 10.1158/1078-0432.CCR-23-2137
PMCID: PMC11287923

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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