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Article

Demographic and genetic factors influence the abundance of infiltrating immune cells in human tissues.

Nature communications - 5 May 2020

Marderstein Andrew R, Uppal Manik, Verma Akanksha, Bhinder Bhavneet, Tayyebi Zakieh, Mezey Jason, Clark Andrew G, Elemento Olivier

Abstract excerpt

Despite infiltrating immune cells having an essential function in human disease and patients' responses to treatments, mechanisms influencing variability in infiltration patterns remain unclear. Here, using bulk RNA-seq data from 46 tissues in the Genotype-Tissue Expression project, we apply cell-type deconvolution algorithms to evaluate the immune landscape across the healthy human body. We discover that 49 of...

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Identifiers

PMID: 32371927
DOI: 10.1038/s41467-020-16097-9
PMCID: PMC7200670

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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