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Article

The role of genomic profiling in adolescents and young adults (AYAs) with advanced cancer participating in phase I clinical trials.

European journal of cancer (Oxford, England : 1990) - 1 May 2018

McVeigh Terri Patricia, Sundar Raghav, Diamantis Nikolaos, Kaye Stan B, Banerji Udai, Lopez Juanita S, de Bono Johann, van der Graaf Winette T A, George Angela J

Abstract excerpt

INTRODUCTION: Adolescents and young adults (AYAs) diagnosed with cancer between ages 15-39 years may harbour germline variants associated with cancer predisposition. Such variants represent putative therapeutic targets, as may somatic variants in the tumour. Germline and tumour molecular profiling is increasingly utilised to facilitate personalisation of cancer treatment in such individuals. AIM: Considering AYAs...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29614442
DOI: 10.1016/j.ejca.2018.02.028
PMCID: PMC6296443

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