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The Epidermal Growth Factor Receptor: A Role in Repair of Radiation-Induced DNA Damage

15 Nov 2007

Abstract excerpt

The epidermal growth factor receptor (EGFR), which is frequently expressed in tumors of epithelial origin, is an important determinant of tumor responses to ionizing radiation. Elevated EGFR expression and activity frequently correlate with tumor resistance to radiotherapy in patients. EGFR is thought to confer tumor resistance to radiation through the activation of survival and cell proliferation pathways....

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PMID: 18006754
DOI: 10.1158/1078-0432.ccr-07-1610

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