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Article

Pro-survival AKT and ERK signaling from EGFR and mutant EGFRvIII enhances DNA double-strand break repair in human glioma cells.

Cancer biology & therapy - 1 Apr 2009

Golding Sarah E, Morgan Rhiannon N, Adams Bret R, Hawkins Amy J, Povirk Lawrence F, Valerie Kristoffer

Abstract excerpt

The epidermal growth factor receptor (EGFR) is frequently dysregulated in malignant glioma that leads to increased resistance to cancer therapy. Upregulation of wild type or expression of mutant EGFR is associated with tumor radioresistance and poor clinical outcome. EGFR variant III (EGFRvIII) is the most common EGFR mutation in malignant glioma. Radioresistance is thought to be, at least in part, the result of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 19252415
DOI: 10.4161/cbt.8.8.7927
PMCID: PMC2863288

Genes

EGFR
ATM
RAD51

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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