Article
Immunohistochemical Analysis of the Metabolic Phenotype of Adrenal Cortical Carcinoma.
Endocrine pathology - 1 Sept 2020
Duan Kai, Gucer Hasan, Kefeli Mehmet, Asa Sylvia L, Winer Daniel A, Mete Ozgur
Abstract excerpt
Metabolic reprogramming is a cellular process contributing to carcinogenesis. However, it remains poorly understood in adrenal cortical carcinoma (ACC), an aggressive malignancy with overall poor prognosis and limited therapeutic options. We characterized the metabolic phenotype of ACC, by examining the immunoprofile of key proteins involved in glucose metabolism, hexokinase (HK1), pyruvate kinase (PKM1, PKM2),...
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