Back to search

Article

Therapy-Associated Oncogenic Axes of Core Cellular and Metabolic Programs Revealed by Multi-Omics Regulatory Network Analysis in Adrenocortical Carcinoma

2025-12-23

Abstract excerpt

Adrenocortical carcinoma (ACC) is a rare and aggressive malignancy with poor prognosis and limited therapies. To elucidate its post-transcriptional regulation, ceRNA networks were reconstructed from TCGA-ACC and GTEx 2025 data. Tumor networks exhibited compact topology and tumor-specific hub miRNAs (miR-466, miR-940, miR-507), which were downregulated, inversely correlated with oncogenic transcripts, and associate...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work
903171fa-31e1-50ad-9bef-67760de99ec5
DOI
10.64898/2025.12.21.25342239
Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest
Interactive article relationship graphSelect a related publication card to move it into the centre and load its closest explainable connections. Solid lines are source-backed structured connections. Dashed lines are semantic discovery signals and are not scientific evidence.
Therapy-Associated Oncogenic Axes of Core Cellular and Metabolic Programs Revealed by Multi-Omics Regulatory Network Analysis in Adrenocortical CarcinomaDOI 10.64898/2025.12.21.25342239
Identification and validation of susceptibility modules and hub genes of adrenocortical carcinoma through WGCNA and machine learningSemantic proximity
Molecular Cluster Mining of Adrenocortical Carcinoma via Multi-Omics Data Analysis Aids Precise Clinical TherapySemantic proximity
Machine learning combining multi-omics data and network algorithms identifies adrenocortical carcinoma prognostic biomarkersSemantic proximity
Identification of key modules and prognostic markers in adrenocortical carcinoma by weighted gene co‑expression network analysisSemantic proximity
A Pan-Cancer Atlas of Metabolic Regulatory Circuitries Integrating Multi-Omic, Immune, and Clinical DimensionsSemantic proximity
miRNAs orchestration of adrenocortical carcinoma - Particular emphasis on diagnosis, progression and drug resistanceSemantic proximity
A Single-Cell Network Approach to Decode Metabolic Regulation in Gynecologic and Breast CancersSemantic proximity
Identification of key genes and pathways in adrenocortical carcinoma: evidence from bioinformatic analysisSemantic proximity
Update on Biology and Genomics of Adrenocortical Carcinomas: Rationale for Emerging TherapiesSemantic proximity
A proteome-based classification of pediatric adrenocortical tumors links functional tumor states to clinical outcome and therapeutic vulnerabilitiesSemantic proximity
Five new hub genes that have an impact on the survival rate of adrenocortical carcinoma were discovered using a correlation network approach in a comprehensive meta-analysisSemantic proximity
Identification and validation of a novel prognosis prediction model in adrenocortical carcinoma by integrative bioinformatics analysis and statistics and machine learningSemantic proximity
Select a neighboring publication to make it the new centre.