Article

A proteome-based classification of pediatric adrenocortical tumors links functional tumor states to clinical outcome and therapeutic vulnerabilities

2026-03-20

Abstract excerpt

Pediatric adrenocortical tumors (pACT) are biologically heterogeneous and incompletely classified by histopathology. To elucidate proteome-level tumor organization, we performed mass spectrometry–based proteomic profiling of 83 pACT and 43 normal adrenal samples. Unsupervised clustering identified four distinct molecular subtypes partially overlapping with histological diagnoses. These subtypes reflected discrete...

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Literature Corpus work: 56647830-29a5-521c-8baf-b47f0fd467dd
DOI: 10.64898/2026.03.18.26348723

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