Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Effect of CFTR Modulators on Airway Infection in Cystic Fibrosis.

International journal of molecular sciences - 23 Mar 2022

Harvey Caitlyn, Weldon Sinead, Elborn Stuart, Downey Damian G, Taggart Clifford

Abstract excerpt

The advent of Cystic fibrosis transmembrane receptor (CFTR) modulators in 2012 was a critical event in the history of cystic fibrosis (CF) treatment. Unlike traditional therapies that target downstream effects of CFTR dysfunction, CFTR modulators aim to correct the underlying defect at the protein level. These genotype-specific therapies are now available for an increasing number of CF patients, transforming the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cystic Fibrosis
Share to Cystic Fibrosis Transmembrane Conductance Regulator

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Progression

Share to Genotype

Share to Mutation

Share to Respiratory System

Source

Open in PubMed Open full text

Identifiers

PMID: 35408875
DOI: 10.3390/ijms23073513
PMCID: PMC8998472

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Effect of CFTR Modulators on Airway Infection in Cystic Fibrosis.PMID 35408875Read ↗

CFTR Modulator Therapies: Potential Impact on Airway Infections in Cystic Fibrosis.Semantic proximity Read ↗

Highly Effective Modulator Therapy: Implications for the Microbial Landscape in Cystic Fibrosis.Semantic proximity Read ↗

The Impact of Highly Effective Modulator Therapy on Cystic Fibrosis Microbiology and Inflammation.Semantic proximity Read ↗

Impact of CFTR Modulators on the Impaired Function of Phagocytes in Cystic Fibrosis Lung Disease.Semantic proximity Read ↗

Diagnosis and Management of Cystic Fibrosis Exacerbations.Semantic proximity Read ↗

Pharmacological correction of CFTR improves systemic inflammation and lung disease in Cystic Fibrosis but does not correct a basic defect in lung repairSemantic proximity Read ↗

Cystic Fibrosis Airway Microbiome: Overturning the Old, Opening the Way for the NewSemantic proximity Read ↗

Effects of CFTR Modulators on Pseudomonas aeruginosa Infections in Cystic FibrosisSemantic proximity Read ↗

Cystic fibrosis: a mucosal immunodeficiency syndrome.Semantic proximity Read ↗

Dysregulated signalling pathways in innate immune cells with cystic fibrosis mutations.Semantic proximity Read ↗

Treating the Airway Consequences of Cystic Fibrosis Transmembrane Conductance Regulator Dysfunction.Semantic proximity Read ↗

Pharmacologic improvement of CFTR function rapidly decreases sputum pathogen density, but lung infections generally persist.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.