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Article

High-resolution melting analysis for rapid and sensitive NOTCH1 screening in chronic lymphocytic leukemia.

International journal of molecular medicine - 1 Feb 2017

Xu Jing-Jing, Yao Fei-Rong, Jiang Min, Zhang You-Tao, Guo Feng

Abstract excerpt

Chronic lymphocytic leukemia (CLL) is a biological and clinical heterogeneous disease. Activating mutations of NOTCH1 have been implicated to be associated with adverse prognosis in CLL. The objective of the present study was to develop an effective high-resolution melting (HRM) assay for detecting NOTCH1 mutations. Genomic DNA (gDNA) extracted from 133 CLL patients was screened by HRM assay, and the results were...

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Share to Cell Line, Tumor
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Share to Polymerase Chain Reaction

Share to Receptor, Notch1

Share to Sensitivity and Specificity

Share to Sequence Analysis, DNA

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Source

Identifiers

PMID: 28075457
DOI: 10.3892/ijmm.2017.2849

Genes

NOTCH1
TAT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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