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Article

High-resolution melting analysis is a more effective approach for screening TSC genes mutations.

Genetic testing and molecular biomarkers - 1 Jun 2011

Tsai Tz-Shiu, Huang Mu-Yi, Chang Yu-Tsui, Wang Chuan-Yu, Lin Ju-Li, Hung Po-Cheng, Lin Shuan-Pei, Sun Chien-Feng, Wang Wei-Shun, Chang Chung-Ming, Chang Shih-Cheng, Chu Da-Chang

Abstract excerpt

Tuberous sclerosis complex (TSC) is an autosomal dominant disorder with a prevalence of 1 in 95,136 in Taiwan. TSC is characterized by hamartomatous lesions in multiple organ systems. Genetic defects in TSC1 and TSC2 genes are the main causes of TSC. A molecular screening protocol using denaturing high-performance liquid chromatography (dHPLC) followed by DNA sequencing is currently performed to locate the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 21510812
DOI: 10.1089/gtmb.2010.0133

Genes

TSC1
TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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