Article
The trio guanine nucleotide exchange factor is a RhoA target. Binding of RhoA to the trio immunoglobulin-like domain.
The Journal of biological chemistry - 17 Nov 2000
Medley Q G, Serra-Pagès C, Iannotti E, Seipel K, Tang M, O'Brien S P, Streuli M
Abstract excerpt
Trio is a complex protein containing two guanine nucleotide exchange factor domains each with associated pleckstrin homology domains, a serine/threonine kinase domain, two SH3 domains, an immunoglobulin-like domain, and spectrin-like repeats. Trio was originally identified as a LAR tyrosine phosphatase-binding protein and is involved in actin remodeling, cell migration, and cell growth. Herein we provide evidence...
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