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Optimization of the PiggyBac Transposon System for the Sustained Genetic Modification of Human T Lymphocytes

15 Sept 2009

Abstract excerpt

Optimal implementation of adoptive T-cell therapy for cancer will likely require multiple and maintained genetic modifications of the infused T cells and their progeny so that they home to tumor sites and recognize tumor cells, overcome tumor immune evasion strategies, and remain safe. Retroviral vectors readily transduce T cells and integrate into the host cell genome, but have a limited capacity for multigene...

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PMID: 19752751
DOI: 10.1097/cji.0b013e3181ad762b

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