Article
Genome-wide mutation analysis in precancerous lesions of endometrial carcinoma.
The Journal of pathology - 1 Jan 2021
Li Lihong, Yue Pinli, Song Qianqian, Yen Ting-Tai, Asaka Shiho, Wang Tian-Li, Beavis Anna L, Fader Amanda N, Jiao Yuchen, Yuan Guangwen, Shih Ie-Ming, Song Yan
Abstract excerpt
Clinicopathological evidence supports endometrial atypical hyperplasia (AH) or endometrial intraepithelial neoplasia as the precursor of uterine endometrioid carcinoma (EC), the most common gynecologic malignancy. However, the pathogenic progression from AH to EC remains unclear. Here, we employed whole-exome sequencing to identify somatic mutations and copy number changes in micro-dissected lesions from 30 pairs...
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