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Article

Structural Basis for the High-Affinity Interaction between CASK and Mint1.

Structure (London, England : 1993) - 2 Jun 2020

Wu Xiandeng, Cai Qixu, Chen Yiyun, Zhu Shihan, Mi Jing, Wang Jiguang, Zhang Mingjie

Abstract excerpt

CASK forms an evolutionarily conserved tripartite complex with Mint1 and Veli critical for neuronal synaptic transmission and cell polarity. The CASK CaM kinase (CaMK) domain, in addition to interacting with Mint1, can also bind to many different target proteins, although the mechanism governing CASK-CaMK/target interaction selectivity is unclear. Here, we demonstrate that an extended sequence in the N-terminal...

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Identifiers

PMID: 32348748
DOI: 10.1016/j.str.2020.04.001

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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