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Article

Linkage of E2F1 transcriptional network and cell proliferation with respiratory chain activity in breast cancer cells.

Cancer science - 1 Jul 2016

Mori Kazunori, Uchida Tetsu, Fukumura Motonori, Tamiya Shigetoshi, Higurashi Masato, Sakai Hirosato, Ishikawa Fumihiro, Shibanuma Motoko

Abstract excerpt

Mitochondria are multifunctional organelles; they have been implicated in various aspects of tumorigenesis. In this study, we investigated a novel role of the basal electron transport chain (ETC) activity in cell proliferation by inhibiting mitochondrial replication and transcription (mtR/T) using pharmacological and genetic interventions, which depleted mitochondrial DNA/RNA, thereby inducing ETC deficiency....

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Identifiers

PMID: 27094710
DOI: 10.1111/cas.12953
PMCID: PMC4946721

Genes

FOXM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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