Article
Structural plasticity of a designer protein sheds light on β-propeller protein evolution.
The FEBS journal - 1 Jan 2021
Mylemans Bram, Laier Ina, Kamata Kenichi, Akashi Satoko, Noguchi Hiroki, Tame Jeremy R H, Voet Arnout R D
Abstract excerpt
β-propeller proteins are common in nature, where they are observed to adopt 4- to 10-fold internal rotational pseudo-symmetry. This size diversity can be explained by the evolutionary process of gene duplication and fusion. In this study, we investigated a distorted β-propeller protein, an apparent intermediate between two symmetries. From this template, we created a perfectly symmetric 9-bladed β-propeller named...
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