Article
Protein plasticity to the extreme: changing the topology of a 4-alpha-helical bundle with a single amino acid substitution.
Structure (London, England : 1993) - 15 Jun 1999
Glykos N M, Cesareni G, Kokkinidis M
Abstract excerpt
BACKGROUND: Conventional wisdom has it that two proteins sharing 98.4% sequence identity have nearly identical three-dimensional structures. Here we provide a counter-example to this statement by showing that a single amino acid substitution can change the topology of a homodimeric 4-alpha-helical bundle protein. RESULTS: We have determined the high-resolution crystal structure of a 4-alpha-helical protein with a...
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