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Article

MEK1/2-PKM2 Pathway Modulates the Immunometabolic Reprogramming of Proinflammatory Allograft-infiltrating Macrophages During Heart Transplant Rejection.

Transplantation - 1 May 2024

Chen Zhang, Li Yuan, Niu Yuqing, Zhang Xi, Yu Jizhang, Cui Jikai, Ran Shuan, Wang Song, Ye Weicong, Xia Jiahong, Wu Jie

Abstract excerpt

BACKGROUND: Emerging evidence has highlighted the role of macrophages in heart transplant rejection (HTR). However, the molecular signals modulating the immunometabolic phenotype of allograft-infiltrating macrophages (AIMs) during HTR remain unknown. METHODS: We analyzed single-cell RNA sequencing data from cardiac graft-infiltrating immunocytes to characterize the activation patterns and metabolic features of...

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Identifiers

PMID: 38238904
DOI: 10.1097/TP.0000000000004899
PMCID: PMC11042528

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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