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Article

Regulatory mechanisms and clinical perspectives of miRNA in tumor radiosensitivity

4 Jul 2012

Abstract excerpt

MicroRNA (miRNA) influences carcinogenesis at multiple stages and it can effectively control tumor radiosensitivity by affecting DNA damage repair, cell cycle checkpoint, apoptosis, radio-related signal transduction pathways and tumor microenvironment. MiRNA also efficiently modulates tumor radiosensitivity at multiple levels by blocking the two essential non-homologous end-joining repair and homologous...

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PMID: 22798379
DOI: 10.1093/carcin/bgs235

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