Article
YY1 downregulation underlies therapeutic response to molecular targeted agents
2024-08-06
Abstract excerpt
<title>Abstract</title> <p>During targeted treatment, oncogene-addicted tumor cells often evolve from initial drug-sensitive state through a drug-tolerant persister bottleneck towards the ultimate emergence of drug-resistant clones. The molecular basis underlying this therapy-induced evolutionary trajectory is not completely elucidated. Here, we employed a multifaceted approach and implicated a convergent role of...
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Identifiers and source
- Literature Corpus work
- 4ebdd4e6-471c-5609-9457-ecb55bc2e03f
- DOI
- 10.21203/rs.3.rs-4595409/v1