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Article

YY1-<i>MIR372</i>-SQSTM1 regulatory axis in autophagy

11 Jun 2014

Abstract excerpt

Autophagy is a self-proteolytic process that degrades intracellular material to enable cellular survival under unfavorable conditions. However, how autophagy is activated in human carcinogenesis remains largely unknown. Herein we report an epigenetic regulation of autophagy in human cancer cells. YY1 (YY1 transcription factor) is a well-known epigenetic regulator and is upregulated in many cancers. We found that...

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Share to Autophagy in Disease and Therapy
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PMID: 24991827
DOI: 10.4161/auto.29486

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