Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Excessive replacement changes drive evolution of global sheep prion protein (PRNP) sequences.

Heredity - 1 May 2022

Sezgin Efe, Teferedegn Eden Yitna, Ün Cemal, Yaman Yalçın

Abstract excerpt

Sheep prion protein (PRNP) is the major host genetic factor responsible for susceptibility to scrapie. We aimed to understand the evolutionary history of sheep PRNP, and primarily focused on breeds from Turkey and Ethiopia, representing genome-wise ancient sheep populations. Population molecular genetic analyses are extended to European, South Asian, and East Asian populations, and for the first time to scrapie...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genetic Predisposition to Disease
Share to Haplotypes
Share to Prion Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Scrapie

Share to Sheep, Domestic

Source

Open in PubMed Open full text

Identifiers

PMID: 35273383
DOI: 10.1038/s41437-022-00520-6
PMCID: PMC9076837

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Excessive replacement changes drive evolution of global sheep prion protein (PRNP) sequences.PMID 35273383Read ↗

Novel Variations in Native Ethiopian Goat breeds PRNP Gene and Their Potential Effect on Prion Protein Stability.Semantic proximity Read ↗

Five Novel PRNP Gene Polymorphisms and Their Potential Effect on Scrapie Susceptibility in Three Native Ethiopian Sheep BreedsSemantic proximity Read ↗

Five novel PRNP gene polymorphisms and their potential effect on Scrapie susceptibility in three native Ethiopian sheep breeds.Semantic proximity Read ↗

Deleterious protein-coding variants in diverse cattle breeds of the world.Semantic proximity Read ↗

Polymorphism of prion protein gene (PRNP) in Nigerian sheep.Semantic proximity Read ↗

Large-scale survey of prion protein genetic variability in scrapie disease-free goats from the United States.Semantic proximity Read ↗

Single nucleotide polymorphisms (SNPs) in the open reading frame (ORF) of prion protein gene (PRNP) in Nigerian livestock species.Semantic proximity Read ↗

The prion protein gene in humans revisited: lessons from a worldwide resequencing study.Semantic proximity Read ↗

Biodiversity and selection for scrapie resistance in sheep: genetic polymorphism in eight breeds of Algeria.Semantic proximity Read ↗

Prion protein gene polymorphisms in Turkish native goat breeds.Semantic proximity Read ↗

Prion protein gene (PRNP) polymorphisms in Xinjiang local sheep breeds in China.Semantic proximity Read ↗

Scrapie-associated polymorphisms of the prion protein gene (PRNP) in Nigerian native goats.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.