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Severe metabolic alterations in liver cancer lead to ERK pathway activation and drug resistance

1 Apr 2020

Abstract excerpt

BACKGROUND: The extracellular signal-regulated kinase (ERK) pathway regulates cell growth, and is hyper-activated and associated with drug resistance in hepatocellular carcinoma (HCC). Metabolic pathways are profoundly dysregulated in HCC. Whether an altered metabolic state is linked to activated ERK pathway and drug response in HCC is unaddressed. METHODS: C-glucose isotope tracing), microarray analysis, and...

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PMID: 32330875
DOI: 10.1016/j.ebiom.2020.102699

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