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Targeting KRAS: from metabolic regulation to cancer treatment

11 Jan 2025

Abstract excerpt

The Kirsten rat sarcoma viral oncogene homolog (KRAS) protein plays a key pathogenic role in oncogenesis, cancer progression, and metastasis. Numerous studies have explored the role of metabolic alterations in KRAS-driven cancers, providing a scientific rationale for targeting metabolism in cancer treatment. The development of KRAS-specific inhibitors has also garnered considerable attention, partly due to the...

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Cancer, Hypoxia, and Metabolism
Cancer-related Molecular Pathways
Metabolism, Diabetes, and Cancer

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 39799325
DOI: 10.1186/s12943-024-02216-3

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