Article
Cancer Metabolism: Phenotype, Signaling and Therapeutic Targets.
Cells - 16 Oct 2020
Park Jae Hyung, Pyun Woo Yang, Park Hyun Woo
Abstract excerpt
Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis, metastasis, drug resistance, and cancer stem cells. Well-known oncogenic signaling pathways, such as phosphoinositide 3-kinase (PI3K)/AKT, Myc, and Hippo pathway, mediate metabolic gene expression and increase metabolic enzyme activities....
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