Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo.

doi:10.1038/s41593-017-0022-z

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Article

Reducing the RNA binding protein TIA1 protects against tau-mediated neurodegeneration in vivo.

Nature neuroscience - 1 Jan 2018

Apicco Daniel J, Ash Peter E A, Maziuk Brandon, LeBlang Chelsey, Medalla Maria, Al Abdullatif Ali, Ferragud Antonio, Botelho Emily, Ballance Heather I, Dhawan Uma, Boudeau Samantha, Cruz Anna Lourdes, Kashy Daniel, Wong Aria, Goldberg Lisa R, Yazdani Neema, Zhang Cheng, Ung Choong Y, Tripodis Yorghos, Kanaan Nicholas M, Ikezu Tsuneya, Cottone Pietro, Leszyk John, Li Hu, Luebke Jennifer, Bryant Camron D, Wolozin Benjamin

Abstract excerpt

Emerging studies suggest a role for tau in regulating the biology of RNA binding proteins (RBPs). We now show that reducing the RBP T-cell intracellular antigen 1 (TIA1) in vivo protects against neurodegeneration and prolongs survival in transgenic P301S Tau mice. Biochemical fractionation shows co-enrichment and co-localization of tau oligomers and RBPs in transgenic P301S Tau mice. Reducing TIA1 decreased the...

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Identifiers

PMID: 29273772
DOI: 10.1038/s41593-017-0022-z
PMCID: PMC5745051

Genes

TIA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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