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Article

Tau Oligomers Associate with Inflammation in the Brain and Retina of Tauopathy Mice and in Neurodegenerative Diseases.

Journal of Alzheimer's disease : JAD - 1 Jan 2017

Nilson Ashley N, English Kelsey C, Gerson Julia E, Barton Whittle T, Nicolas Crain C, Xue Judy, Sengupta Urmi, Castillo-Carranza Diana L, Zhang Wenbo, Gupta Praveena, Kayed Rakez

Abstract excerpt

It is well-established that inflammation plays an important role in Alzheimer's disease (AD) and frontotemporal lobar dementia (FTLD). Inflammation and synapse loss occur in disease prior to the formation of larger aggregates, but the contribution of tau to inflammation has not yet been thoroughly investigated. Tau pathologically aggregates to form large fibrillar structures known as tangles. However, evidence...

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Identifiers

PMID: 27716675
DOI: 10.3233/JAD-160912
PMCID: PMC5147514

Genes

HMGB1

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