Whole Exome Sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target.

doi:10.3324/haematol.2019.238766

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Whole Exome Sequencing reveals NOTCH1 mutations in anaplastic large cell lymphoma and points to Notch both as a key pathway and a potential therapeutic target.

Haematologica - 1 Jun 2021

Larose Hugo, Prokoph Nina, Matthews Jamie D, Schlederer Michaela, Högler Sandra, Alsulami Ali F, Ducray Stephen P, Nuglozeh Edem, Fazaludeen Feroze M S, Elmouna Ahmed, Ceccon Monica, Mologni Luca, Gambacorti-Passerini Carlo, Hoefler Gerald, Lobello Cosimo, Pospisilova Sarka, Janikova Andrea, Woessmann Wilhelm, Damm-Welk Christine, Zimmermann Martin, Federova Alina, Malone Andrea, Smith Owen, Wasik Mariusz, Inghirami Giorgio, Lamant Laurence, Blundell Tom L, Klapper Wolfram, Merkel Olaf, Burke Amos G A, Mian Shahid, Ashankyty Ibraheem, Kenner Lukas, Turner Suzanne D

Abstract excerpt

Patients diagnosed with Anaplastic Large Cell Lymphoma (ALCL) are still treated with toxic multi-agent chemotherapy and as many as 25-50% of patients relapse. To understand disease pathology and to uncover novel targets for therapy, Whole-Exome Sequencing (WES) of Anaplastic Lymphoma Kinase (ALK)+ ALCL was performed as well as Gene-Set Enrichment Analysis. This revealed that the T-cell receptor (TCR) and Notch...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32327503
DOI: 10.3324/haematol.2019.238766
PMCID: PMC8168516

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