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Article

HIV-1 Vpr Abrogates the Effect of TSG101 Overexpression to Support Virus Release.

PloS one - 1 Jan 2016

Chutiwitoonchai Nopporn, Siarot Lowela, Takeda Eri, Shioda Tatsuo, Ueda Motoki, Aida Yoko

Abstract excerpt

HIV-1 budding requires interaction between Gag and cellular TSG101 to initiate viral particle assembly and release via the endosomal sorting complexes required for transport (ESCRT) pathway. However, some reports show that overexpression of TSG101 inhibits virus release by disruption of Gag targeting process. Since a HIV-1 accessory protein, Vpr binds to Gag p6 domain at the position close to the binding site for...

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Share to Endosomal Sorting Complexes Required for Transport
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescence Resonance Energy Transfer

Share to Gene Products, gag

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Share to vpr Gene Products, Human Immunodeficiency Virus

Source

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Identifiers

PMID: 27648839
DOI: 10.1371/journal.pone.0163100
PMCID: PMC5029901

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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