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Targeting STAT3 and oxidative phosphorylation in oncogene-addicted tumors

13 Dec 2018

Abstract excerpt

Drug resistance invariably limits the response of oncogene-addicted cancer cells to targeted therapy. The upregulation of signal transducer and activator of transcription 3 (STAT3) has been implicated as a mechanism of drug resistance in a range of oncogene-addicted cancers. However, the development of inhibitors against STAT3 has been fraught with challenges such as poor delivery or lack of specificity. Clinical...

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PMID: 30594485
DOI: 10.1016/j.redox.2018.101073

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