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Antileukemic Activity of 2-Deoxy-d-Glucose through Inhibition of N-Linked Glycosylation in Acute Myeloid Leukemia with FLT3-ITD or c-KIT Mutations.

Molecular cancer therapeutics - 1 Oct 2015

Larrue Clément, Saland Estelle, Vergez François, Serhan Nizar, Delabesse Eric, Mansat-De Mas Véronique, Hospital Marie-Anne, Tamburini Jérôme, Manenti Stéphane, Sarry Jean Emmanuel, Récher Christian

Abstract excerpt

We assessed the antileukemic activity of 2-deoxy-d-glucose (2-DG) through the modulation of expression of receptor tyrosine kinases (RTK) commonly mutated in acute myeloid leukemia (AML). We used human leukemic cell lines cells, both in vitro and in vivo, as well as leukemic samples from AML patients to demonstrate the role of 2-DG in tumor cell growth inhibition. 2-DG, through N-linked glycosylation inhibition,...

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Source

Identifiers

PMID: 26206337
DOI: 10.1158/1535-7163.MCT-15-0163

Genes

KIT
FLT3
STAT3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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