Article
Mechanisms of FH Protection Against Neovascular AMD.
Frontiers in immunology - 1 Jan 2020
Borras Céline, Delaunay Kimberley, Slaoui Yousri, Abache Toufik, Jorieux Sylvie, Naud Marie-Christine, Sanharawi Mohamed El, Gelize Emmanuelle, Lassiaz Patricia, An Na, Kowalczuk Laura, Ayassami Cédric, Moulin Alexandre, Behar-Cohen Francine, Mascarelli Frédéric, Dinet Virginie
Abstract excerpt
A common allele (402H) of the complement factor H (FH) gene is the major risk factor for age-related macular degeneration (AMD), the leading cause of blindness in the elderly population. Development and progression of AMD involves vascular and inflammatory components partly by deregulation of the alternative pathway of the complement system (AP). The loss of central vision results from atrophy and/or from...
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