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Article

The FCGR3A 158 V/V-genotype is associated with decreased survival of renal allografts with chronic active antibody-mediated rejection.

Scientific reports - 12 Apr 2021

Litjens Nicolle, Peeters Annemiek, Gestel Judith Kal-van, Klepper Mariska, Betjes Michiel

Abstract excerpt

Natural killer (NK) cells express the Fc-gamma receptor CD16 (FCGR3A) and could therefore mediate renal endothelial cell damage in cases of chronic-active antibody mediated rejection (c-aABMR). The V/V-genotype of the FCGR3A 158 F/V polymorphism is associated with increased CD16 expression and cytotoxicity by NK cells. This study evaluated whether this genotype is associated with the diagnosis of c-aABMR and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 33846428
DOI: 10.1038/s41598-021-86943-3
PMCID: PMC8041758

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