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Article

APOE ε4 and cognitive reserve effects on the functional network in the Alzheimer's disease spectrum.

Brain imaging and behavior - 1 Apr 2021

Li Ting, Wang Bin, Gao Yuan, Wang Xin, Yan Ting, Xiang Jie, Niu Yan, Liu Tiantian, Chen Duanduan, Fang Boyan, Xie Yunyan, Funahashi Shintaro, Yan Tianyi

Abstract excerpt

The apolipoprotein E (APOE) ε4 allele is a genetic risk factor for Alzheimer's disease, whereas educational attainments have protective effects against cognitive decline in aging and patients with Alzheimer's disease. We examined the possible effects of years of education and APOE genotype on the topological properties of the functional network in normal aging, mild cognitive impairment and Alzheimer's disease....

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PMID: 32314201
DOI: 10.1007/s11682-020-00283-w

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