Article
Circulating tumor DNA predicts response in Chinese patients with relapsed or refractory classical hodgkin lymphoma treated with sintilimab.
EBioMedicine - 1 Apr 2020
Shi Yuankai, Su Hang, Song Yongping, Jiang Wenqi, Sun Xiuhua, Qian Wenbin, Zhang Wei, Gao Yuhuan, Jin Zhengming, Zhou Jianfeng, Jin Chuan, Zou Liqun, Qiu Lugui, Li Wei, Yang Jianmin, Hou Ming, Xiong Yan, Zhou Hui, Du Xinhua, Wang Xiong, Peng Bo
Abstract excerpt
BACKGROUND: Blood-based biomarker such as circulating tumor DNA (ctDNA) has emerged as a promising tool for assessment of response to immunotherapy in solid tumors; But in hematological malignances, evidences are still lacking to support its clinical utility. In current study the feasibility of ctDNA for prediction and monitoring of response to anti-PD-1 therapy in Chinese patients with relapsed or refractory...
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